Colorectal Cancer Nutritional Guide - Specialized Personalized Meal Plan

Complete Nutritional Guide Colon Cancer

Complete Nutritional Guide for Colon Cancer Management

I. Introduction and Key Nutritional Principles

This section outlines the fundamental role of nutrition in colon cancer management and details the key principles underlying the dietary plans for the individual for whom the plan was developed. You will find information on individualized caloric and protein needs, the importance of cooked tomatoes and hydration, strategies to support the immune system, and an analysis of medical dietary recommendations.

A. Overview of the Role of Nutrition in Colon Cancer

Nutrition plays a fundamental role in colon cancer management, influencing patient prognosis and quality of life. A strategic nutritional approach is essential for preparing the body for surgery, supporting recovery, and maintaining long-term health.

B. Calculating Individualized Caloric and Protein Needs

For the example individual (born in 1956, assuming 68 years at the time of planning, 59 kg, 166 cm), the needs were calculated as follows:

  • Basal Metabolic Rate (BMR): 1292.5 kcal/day (calculated with Mifflin-St Jeor)
  • TDEE (Sedentary Level, factor 1.2): 1551 kcal/day
  • TDEE (Lightly Active Level, factor 1.375): 1777 kcal/day
  • Minimum Protein Requirement (1.0 g/kg): 59 g/day
  • Optimal Protein Requirement (1.2-1.5 g/kg): 71-89 g/day

These values are estimates and will guide the dietary plans, adjusted according to individual tolerance and the specific objectives of each stage.

C. Specific Role of Cooked Tomatoes (Lycopene) and Hydration

Cooked Tomatoes and Lycopene: Including cooked tomatoes (boiled, baked, in sauces, without skin and seeds during sensitive phases) is beneficial due to lycopene, a powerful antioxidant, which is better absorbed from heat-processed tomatoes. An intake of 5-7 mg of lycopene/day is considered beneficial and can be achieved through regular consumption.

Hydration: Consuming at least 1.5-2 liters of fluids per day (water, unsweetened herbal teas, clear soups) is crucial, especially in the context of a low-fiber pre-operative diet and for post-operative recovery. In the long term, adequate hydration supports normal intestinal function.

D. Nutritional Strategies for Immune System Support

A holistic nutritional approach supports the immune system. Adequate protein (for tissue repair and antibody production), vitamins (A, C, D, E, B6, B12, folic acid) and minerals (zinc, selenium, iron, copper) in recommended doses, as well as antioxidants (e.g., lycopene from tomatoes, beta-carotene from carrots, flavonoids from allowed fruits and vegetables) are important. Preventing malnutrition and maintaining a healthy weight are key strategies.

E. Approach to the List of Permitted/Forbidden Foods by the Treating Physician (Comparative Analysis Pre-Operative)

Most restrictions imposed by the treating physician are consistent with the principles of a low-residue pre-operative diet, intended to minimize intestinal content. Strict adherence to the doctor's instructions before surgery is paramount.

Food/Group Physician's Recommendation (Pre-Op) Alignment with Low-Residue Diet
Buttermilk, yogurt, kefir, fermented cheeses Forbidden Correct (may stimulate transit/ferment)
Hard-boiled eggs Forbidden (soft-boiled allowed) Correct (harder to digest)
Mayonnaise Forbidden Correct (fats, irritating)
Sturgeon roe Forbidden Correct (fatty, potentially irritating)
Canned fish Forbidden Correct (often in oil/sauces, salt)
Cold cuts, smoked meats, sausages Forbidden Correct (processed, fatty, irritating)
Bell peppers, radishes, beans, lentils, peas, mushrooms, celery, garlic, leeks, chili peppers, cucumbers Forbidden Correct (most are high in fiber/irritating)
Condiments: mustard, horseradish, pickles, pepper Forbidden Correct (irritating)
Drinks/Sweets: coffee, chocolate Forbidden Correct (stimulants, irritating)
Milk, cottage cheese, fresh whey cheese, fresh unsalted cheese Allowed Correct (lean, non-fermented varieties)
Lean meat (beef, poultry), lean river fish Allowed Correct (good sources of protein, easily digestible if dietetically prepared)
Soft-boiled eggs, diet omelet Allowed Correct
Day-old white bread, semolina, rice Allowed Correct (low in fiber)
Cream soups, purees, puddings Allowed Correct (from allowed vegetables, strained, soft texture)
Baked potatoes Allowed Correct (without skin)
Fruit tarts, butter, sour cream Allowed In moderation (white dough, allowed fruits, watch out for fats)
Herbal teas Allowed Correct (unsweetened, non-irritating)

II. Pre-Operative Dietary Plan (Low Fiber – 30 Days)

This section is dedicated to the diet for 30 days before surgery. The focus is on a low-fiber (low-residue) and high-protein diet to prepare the colon for surgery. You will find principles, detailed lists of allowed and forbidden foods, preparation techniques, and an example daily menu. The ERAS protocol can be discussed with the doctor.

A. Principles and Justification of the Low-Residue Diet

The low-fiber diet reduces stool volume and frequency of bowel movements, "resting" the colon and facilitating its cleansing for surgery. It is a temporary measure, essential in pre-operative preparation. Protein intake is maintained or increased to support the body.

B. Detailed Guide: Allowed and Forbidden Foods in the Pre-Operative Diet

Grains and Bakery Products:

Allowed: White bread (day-old or toasted), white flour pasta, husked white rice, semolina, plain cornflakes, plain white flour biscuits (e.g., plain digestive biscuits).

Avoid: Wholemeal/rye/seed/bran bread, wholemeal pastries, brown/wild rice, wholemeal pasta, high-fiber whole grains (e.g., whole oat flakes), popcorn.

Vegetables:

Allowed: Potatoes (peeled, boiled/baked/pureed), carrots (peeled, well-cooked, mashed), zucchini (peeled/deseeded, boiled/baked), strained tomato juice, baked/boiled tomatoes (peeled/deseeded, in moderate amounts). Young green beans (very well cooked, small amounts, only if specifically permitted by the doctor and cause no discomfort).

Avoid: All raw vegetables, vegetables with unremoved skin/seeds, broccoli, cabbage (all types), cauliflower, raw/cooked celery (if fibrous), garlic, onion, leeks (especially raw or in large quantities), peppers (especially raw or with skin), cucumbers, mushrooms, corn kernels, peas, lentils, dried beans.

Fruits:

Allowed: Ripe bananas, apples (peeled, boiled/baked, pureed), pears (peeled, boiled/baked, pureed), canned fruits (peeled/pitted, e.g., peaches, apricots), clear, strained fruit juices (without pulp/added sugar, e.g., clear apple juice).

Avoid: Raw fruits with skin/seeds (e.g., strawberries, raspberries, kiwi), dried fruits (prunes, raisins, dates), nuts, hazelnuts, seeds (flax, chia, sesame, etc.), coconut, fresh pineapple, whole citrus fruits (strained lemon juice may be allowed in small amounts), fresh plums/prune juice.

Meat, Fish, Eggs:

Allowed: Lean beef/poultry (chicken, turkey, skinless/visible fat removed, boiled/baked/grilled/stewed), lean fish (cod, pike-perch, trout, hake - boiled/baked/steamed), soft-boiled eggs (soft yolk), diet omelet (from whole eggs or whites only, prepared with minimal fat).

Avoid: Fatty meat (fatty pork, lamb), processed meat (cold cuts, sausages, hot dogs, salami, parizer), canned fish in oil/tomato sauce, roe, hard-boiled eggs, fried or heavily spiced meat.

Dairy:

Allowed: Sweet milk (skimmed/partially skimmed, if tolerated and does not cause bloating), fresh lean cottage cheese, fresh whey cheese, fresh unsalted/unfermented cheese. Lean sour cream (10-12% fat) and butter in small quantities (e.g., 5g per meal), if tolerated.

Avoid: Buttermilk, sana, kefir, yogurt (especially those with fruit or whole grains, as per doctor's instructions), fermented, aged, moldy cheeses, fatty sour cream.

Fats and Oils:

Allowed: Butter (small quantities), spreadable margarine (in moderation), vegetable oils (olive, sunflower) used in moderation for cooking (not frying).

Avoid: Mayonnaise, fried foods, excessive animal fats (lard, bacon), fatty commercial sauces.

Beverages:

Allowed: Still water (minimum 1.5-2L/day), non-irritating herbal teas (chamomile, linden, St. John's wort – unsweetened or very lightly sweetened with honey if allowed), clear strained fruit juices (apple, white grape – without added sugar).

Avoid: Coffee, black/green tea (if prohibited by doctor), hot chocolate/cocoa, pulpy juices, nectars, carbonated drinks, alcohol in any form.

Condiments and Sweets:

Allowed: Salt (moderately), mild dried or fresh aromatic herbs (dill, parsley, lovage, thyme – if tolerated, in small amounts), vanilla, cinnamon (very little). Honey, sugar (in great moderation), plain jellies (from clear juice), fine jams/preserves (without seeds/skins, with low sugar content, e.g., from apples, pears), homemade semolina/rice puddings with skimmed milk, tarts with white dough and permitted fruit filling (e.g., grated cooked apples).

Avoid: Pepper (black, white, red), hot paprika, mustard, horseradish, pickles, excessive vinegar, hot/exotic spices. Concentrated commercial sweets, cakes with fatty creams, puff pastry products, chocolate (as per doctor's instructions).

C. Food Preparation Techniques

Boiling (in water/steam), baking (in a covered dish/baking paper), stewing (with minimal added fat and water/broth), and grilling (for lean meat/fish, without charring and without prolonged direct contact with flame) are recommended. Avoid frying. Vegetables should be cooked very soft, until tender. Meat should be tender and easy to chew. Remove skins and seeds from allowed fruits/vegetables.

D. ERAS Protocol and Carbohydrate Loading

The ERAS (Enhanced Recovery After Surgery) protocol aims to accelerate post-operative recovery. An important component is pre-operative carbohydrate loading, which helps reduce metabolic stress induced by surgery and improve glycemic control.

Recommendations (MUST discuss with the anesthesiologist/surgeon before proceeding):

  • Evening before surgery (e.g., 8:00-10:00 PM): Consumption of a carbohydrate-rich drink, providing approximately 80-100g of carbohydrates (e.g., 800-950ml of clear, unsweetened apple juice, or special pre-operative drinks if indicated by the doctor).
  • Morning of surgery, 2-3 hours before anesthesia induction (NO later): Consumption of a drink providing approximately 40-50g of carbohydrates (e.g., 400-475ml of clear apple juice or special drink).

Juices must be clear, without pulp, to avoid leaving residues in the stomach. Avoid citrus juices or those with high acidity. It is essential that these liquids be consumed up to the time limit indicated by the medical team (usually 2 hours for clear liquids before anesthesia).

Contraindications and Precautions: This protocol is not suitable for all patients. Contraindications may include poorly controlled diabetes mellitus (especially type 1 or insulin-dependent type 2), severe gastroparesis (delayed gastric emptying), severe gastroesophageal reflux, previous gastric surgeries affecting stomach emptying, massive ascites, dysphagia (difficulty swallowing). The doctor will assess the eligibility of the individual concerned.

E. Example Daily Pre-Operative Menu (Day 1 of 30)

This is an example; variations are necessary for the 30 days, respecting caloric targets (approx. 1600-1750 kcal) and protein targets (approx. 70-85g). Cooked tomatoes (without skin/seeds) are included.

Breakfast (approx. 350 kcal, 20g protein)

Preparation: Diet omelet from 2 eggs (or 1 whole egg and 2 whites), with 50g fresh lean cottage cheese, dill.

Method of preparation: Beat the eggs with a pinch of salt and chopped dill. Cook in a non-stick pan greased with 1 teaspoon of olive oil, over low heat, until set but still soft. Serve with cottage cheese.

Accompaniment: 1 slice of toasted white bread (30g), unsweetened chamomile tea.

Lunch (approx. 650 kcal, 35g protein)

Preparation: Clear chicken soup with homemade noodles (from white flour); Chicken breast (150g) baked with mashed potatoes (200g) and strained baked tomato sauce (100ml).

Soup: Boil chicken bones and allowed vegetables (carrot, parsnip – strain at the end). Add homemade noodles (30g raw) and boil. You can also add small pieces of boiled chicken (50g) to the soup.

Main Course: Bake chicken breast, seasoned with salt and allowed herbs. Boil potatoes (peeled), mash with a little skimmed milk and 5g butter. Prepare the sauce from baked tomatoes (peeled and deseeded), mashed and strained, seasoned with salt and a little dried basil.

Dinner (approx. 550 kcal, 30g protein)

Preparation: Trout (150g) baked in baking paper with white rice (70g raw, ~200g cooked) and boiled baby carrots (100g).

Method of preparation: Season the trout with salt and a little lemon juice (if tolerated and allowed), wrap in baking paper with a thin slice of lemon and sprigs of dill. Bake until tender. Boil white rice. Boil baby carrots (peeled) until very soft.

Note: This menu is an example. Throughout the 30 days, the types of lean meat (turkey, lean beef), lean fish (cod, pike-perch), preparation methods for eggs and permitted dairy, and recipes with cooked tomatoes (e.g., strained tomato juice added to diet stews, baked tomatoes as a side dish) will be varied. Food rotation will be ensured to avoid monotony and cover nutritional needs within the low-fiber diet.

III. Post-Operative Dietary Plan (Immediate Recovery and Transition – First 4 Weeks)

This section describes nutrition after surgery, essential for healing and recovery. It includes general principles, details Phase 1 (immediate recovery) and Phase 2 (transition to a normalized diet, with fiber reintroduction), and provides examples of progressively adapted menus.

A. General Principles of Immediate Post-Operative Nutrition

Oral feeding is resumed early (usually within the first 24 hours post-op, according to the ERAS protocol and doctor's instructions), gradually: clear liquids -> full liquid diet -> soft/semi-solid diet (low in fat/fiber). Small, frequent meals (5-6/day) are recommended to avoid overworking the digestive system. Tolerance is individual and guides progression. Adequate hydration is essential.

B. Phase 1: Immediate Post-Operative Recovery (First ~1-2 weeks)

Week 1 (Days 1-7 post-operative):

Days 1-2 (according to strict medical indications): Clear liquid diet (still water, unsweetened chamomile tea, very weak vegetable/chicken broth, only strained liquid, plain unsweetened gelatin). Small, fractional quantities (e.g., 50-100ml every 1-2 hours).

Days 3-7 (progressively, depending on tolerance and return of bowel function): Full liquid diet. May add: skimmed/lactose-free milk, plain, skimmed natural yogurt (if permitted and tolerated), fine, very well-strained cream soups, from allowed vegetables (carrot, zucchini, potato – peeled/deseeded). Towards the end of the week, if tolerance is good, semi-solid/soft foods may be introduced: fine purees of allowed vegetables, very well-cooked and finely mashed chicken/white fish, soft-boiled egg (yolk only initially, then white if tolerated), fresh, lean, mashed cottage cheese. Strained tomato juice or very fine tomato cream soup (without skin/seeds) in very small quantities for testing, if permitted by the doctor.

Week 2 (Days 8-14 post-operative):

Continue soft diet, slightly more consistent textures, but very low fiber and fat content. May introduce: toasted white bread (initially without crust, then with crust if tolerated), plain white flour biscuits. Allowed fruits (ripe bananas, boiled/baked and mashed apples/pears, peeled) in small portions. Protein intake should be gradually increased through lean boiled/baked and finely minced meat, lean fish, eggs, permitted dairy. Cooked tomatoes (fine sauce, strained, added to pasta/rice) may be tried in small amounts.

C. Phase 2: Transition to a Normalized Diet (Weeks ~3-4 and beyond)

Gradual Reintroduction of Dietary Fiber (with caution, as advised by the doctor):

This is a crucial stage and must be done slowly, carefully monitoring tolerance. Start with small amounts of soluble fiber, which are gentler on the digestive system.

Practical Guide for Post-Operative Fiber Reintroduction (Immediate)
Post-Op Week (approx.) New Fibrous Food Introduced Initial Quantity / Preparation Method Notes / Progression
Week 2-3 (with medical approval) Fine oat flakes (not whole) 2-3 level tablespoons, well cooked in water/skimmed milk Slow increase in quantity if tolerated.
Cooked carrot (peeled) 1/2 small carrot, very well cooked and mashed Gradual addition to soups/purees.
Week 3-4 Baked/boiled apple (peeled) 1/2 small apple, mashed Test with thin skin much later.
White bread (normal texture, not just toasted) 1 slice/day Switch to soft wholemeal bread only after several weeks of good tolerance.
Week 4+ (very gradually) Brown rice (very well cooked) 1-2 tablespoons at a meal Slow increase, alternating with white rice.
Well-cooked vegetables (e.g., zucchini with a little skin, young green beans) Small portions (50-100g) Introduce only one new type every few days.
Week 6-8+ (with much caution) Broccoli/cauliflower (florets only, very well cooked) 1-2 small florets May cause gas; introduce very slowly.
Much later (months) Beans/lentils (well cooked, initially mashed) 1-2 tablespoons puree Very gradual increase, may cause bloating.

Each new food is introduced individually, in small quantities, every 2-3 days, to identify any intolerances (bloating, cramps, diarrhea). Increase fluid intake as fiber intake increases.

D. Example Post-Operative Daily Menus (Progressive in the First 4 Weeks)

Example Days 3-5 Post-Operative (Phase 1 – Full liquid/very soft semi-solid diet)

Breakfast (approx. 200 kcal, 8g P)

Chamomile tea. Plain, skimmed natural yogurt (100g) OR skimmed milk (1 glass, 200ml).

Lunch (approx. 300 kcal, 15g P)

Cream of chicken soup (50g finely mashed boiled chicken breast, 1/2 small boiled and mashed potato, in 200ml clear strained chicken broth). A little boiled and mashed carrot can also be added.

Dinner (approx. 250 kcal, 12g P)

Fine mashed potatoes (100g) with fresh, lean, mashed cottage cheese (50g). Optional: 1 teaspoon olive oil in the mash.

Snacks (every 2-3 hours): Strained carrot soup (150ml), plain gelatin from clear apple juice (100g), allowed teas.

Example Days 10-14 Post-Operative (Phase 1 – Soft diet)

Breakfast (approx. 280 kcal, 12g P)

Diet omelet (1 whole egg or 1 white and 1 yolk) cooked steamed or in a non-stick pan with minimal oil. 1 slice toasted white bread (without crust). Linden tea.

Lunch (approx. 450 kcal, 30g P)

Boiled and finely minced chicken breast (100g) with carrot puree (150g) and well-cooked white rice (100g cooked). Strained tomato juice (50ml) can be added over the rice, if tolerated.

Dinner (approx. 350 kcal, 25g P)

Lean white fish (cod, pike-perch - 120g) baked in foil with a little olive oil and lemon, served with plain potatoes (boiled, peeled, 150g).

Snacks: Ripe banana (1/2), plain natural yogurt (100g), apple compote (peeled, mashed).

Example Week 3-4 Post-Operative (Phase 2 – Beginning of fiber reintroduction)

Breakfast (approx. 350 kcal, 15g P)

Fine oat flakes (30g raw) cooked in skimmed milk (200ml) with 1/2 ripe, mashed banana, or 1/2 baked apple (peeled), mashed.

Lunch (approx. 500 kcal, 35g P)

Chicken soup with fine noodles (from white flour) and soft-cooked vegetables (carrot, parsnip, zucchini – 50g each, mashed if needed). Turkey stew (120g lean meat) with mashed potatoes (150g) and strained baked tomato sauce (100g, peeled/deseeded).

Dinner (approx. 400 kcal, 30g P)

Pike-perch fillet grilled or baked (150g) with white or brown rice (very well cooked, 100g cooked – brown rice introduced with caution) and boiled zucchini (100g, peeled, or with thin skin if tolerated).

Snacks: Fresh cottage cheese (50g) with plain biscuits (2-3 pcs.), allowed cooked/baked fruits.

IV. Detailed Dietary Plan – 30 Days (Long-Term Stage, Over 6 Months Post-Operative)

General Principles (Long-Term Stage):

This plan is designed for the period after complete recovery (usually over 6 months post-operative), when digestive tolerance is good and a varied diet has been resumed. It is based on the principles of a balanced, nutrient-rich diet, with adequate intake of fiber, quality protein, and healthy fats, maintaining the regular inclusion of cooked tomatoes.

Estimated Daily Targets:

  • Calories: ~1800-2000 kcal (adjustable according to activity level and weight maintenance)
  • Protein: ~70-90 g (1.2-1.5 g/kg body weight)
  • Fiber: ~25-35 g (introduced gradually and according to individual tolerance)

General Note:

  • This plan is an example and can be adapted to individual preferences, respecting nutritional principles.
  • Include a wide variety of colorful vegetables and fruits.
  • Choose whole grains (wholemeal bread, brown rice, quinoa, oats, etc.).
  • Consume legumes (beans, lentils, chickpeas) 2-3 times a week, if well tolerated.
  • Prefer lean meats (chicken, turkey, fish) and limit processed red meat.
  • Include healthy fats (extra virgin olive oil, avocado, nuts, seeds).
  • Constant hydration: minimum 2 liters of water per day.
  • Regular physical activity is essential.
Day Breakfast (B) Lunch (L) Dinner (D) Est. Total Calories (Day) Est. Total Protein (Day)
Detailed 30-day meal plan, long-term stage. Recipes are summarized; consult a dietitian for complete details and personalized adaptation.

V. Additional Recommendations and Continuous Monitoring

This final section provides practical advice for managing common post-operative digestive symptoms, emphasizes the importance of adapted physical activity, monitoring nutritional status, and constant communication with the medical team for optimal recovery and long-term health maintenance.

A. Management of Common Digestive Symptoms

Bloating and Gas: Chew food slowly and completely. Avoid carbonated drinks and straw use. Introduce new foods, especially high-fiber ones, gradually and in small amounts. Certain teas (mint, fennel, ginger – if tolerated) may help.

Constipation: Ensure adequate hydration (minimum 2 liters of water/day). Gradually increase fiber intake from fruits, vegetables, and whole grains, according to tolerance. Regular light exercise (walking) stimulates bowel movements. Do not use laxatives without medical advice.

Diarrhea: If it occurs, rehydrate with water, unsweetened herbal teas, clear soups, oral rehydration solutions (if severe). Temporarily revert to more astringent and low-fiber foods (cooked white rice, ripe bananas, baked/boiled apples, toasted white bread, boiled chicken). Avoid milk (except for plain natural yogurt, if tolerated), fatty foods, fried foods, concentrated sweets, hot spices. Inform your doctor if diarrhea is severe, persistent, or accompanied by fever/blood in the stool.

B. Role of Adapted Physical Activity

Immediately Post-operative (with medical approval): Gradual resumption of movement is encouraged (e.g., light walking in the ward/at home). It helps prevent complications (thrombosis, pneumonia) and stimulates the resumption of intestinal transit.

Long-term (after complete healing and with doctor's consent): Regular physical activity is extremely beneficial. It contributes to maintaining a healthy weight, improves mood, muscle tone, and can reduce the risk of cancer recurrence and the onset of other chronic diseases. A minimum of 150-300 minutes of moderate-intensity physical activity (brisk walking, swimming, light cycling) or 75-150 minutes of vigorous-intensity physical activity per week is recommended, plus strength exercises twice a week.

C. Importance of Monitoring Nutritional Status and Weight

Monitoring body weight (e.g., weekly weighing, under the same conditions) is important to promptly identify unintended weight loss or excessive gains. Appetite fluctuations are normal during recovery; however, persistent inappetence, difficulty swallowing, or early satiety leading to insufficient food intake and weight loss require medical and dietary evaluation. A food diary can be useful for tracking intake and tolerance.

D. Communication with the Medical Team

Maintain open and constant communication with your treating doctors (oncologist, surgeon, family doctor) and clinical dietitian. Promptly discuss any issues related to diet, digestive tolerance, weight changes, new symptoms, or worsening of existing ones. The nutritional plan is dynamic and may require periodic adjustments based on the evolution of health status.

E. Conclusions and Final Recommendations

This nutritional guide provides a framework based on scientific evidence and general recommendations for colon cancer management. The dietary plans presented aim to optimize nutritional status in the pre-operative stage, support effective post-operative recovery, and promote a healthy and balanced long-term eating style, adapted to individual needs. Strict adherence to the treating doctor's instructions and careful monitoring of individual tolerance are essential for the success of nutritional intervention. Adequate hydration, regular physical activity, and periodic medical check-ups are equally important pillars in maintaining health and quality of life.

*This report and the dietary plans are provided for informational and educational purposes only and do not replace direct and personalized medical consultation or the advice of a clinical dietitian. Any decision regarding the diet and treatment of the person concerned must be made in conjunction with the treating physicians.*

Information extracted and adapted from "Personalized Nutritional Guide for Colon Cancer Management". Created for interactive exploration.

Disclaimer: This material is for informational purposes only and does not substitute professional medical advice. Health decisions should be made in conjunction with the medical team.